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Harding (1985) "The brain RAS and Alzheimer's disease." Exp Neurol 223(2): 326-33

Because an oral 15-PGDH inhibitor has already passed Phase 1 safety testing in humans for age-related #muscle weakness, the authors are hopeful that clinical trials in joint disease will follow, potentially paving the way for #nonsurgical, cartilage-regenerating therapies that could delay or replace knee and hip replacements

The peptide has been studied in laboratory and preclinical settings and is used in cosmetics, but it has not completed the FDA drug-approval process for a medical indication

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